July 18, 2025
How Environment and Mindset Rewrite Your Health Story with Dr. Mark Sherwood
Send us a text Your genes are not a prison, they’re a roadmap. In this episode, Dr. Mark Sherwood unpacks how stress, trauma, and environment—not just DNA—shape your long-term health and healing. Have you ever felt afraid to learn what your genes say about you? You’re not alone—but here’s the truth: your DNA isn’t destiny. It’s a draft. And in this week’s powerful conversation with Dr. Mark Sherwood, you’ll learn how to rewrite that draft every day through your lifestyle, mindset, and even pe...
Your genes are not a prison, they’re a roadmap. In this episode, Dr. Mark Sherwood unpacks how stress, trauma, and environment—not just DNA—shape your long-term health and healing.
Have you ever felt afraid to learn what your genes say about you?
You’re not alone—but here’s the truth: your DNA isn’t destiny. It’s a draft. And in this week’s powerful conversation with Dr. Mark Sherwood, you’ll learn how to rewrite that draft every day through your lifestyle, mindset, and even peptide-based medicine.
Dr. Sherwood shares how environmental stress, trauma, and cortisol can shut down healthy gene expression and what to do instead. We also explore the most misunderstood SNPs (like MTHFR and APOE4), the hype around direct-to-consumer testing, and how personalized medicine is evolving into a future powered by proteomics and peptides.
BY THE TIME YOU FINISH LISTENING, YOU’LL DISCOVER:
- Why knowing your genes isn’t the problem - misusing them is
- How trauma and stress suppress your body's ability to heal at the cellular level
- What peptide-based therapies and proteomic testing mean for the future of personalized wellness
Your genes might explain your tendencies, but they don’t dictate your outcomes.
CONNECT WITH DR. MARK SHERWOOD
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00:01 - Understanding Genetic Expression
03:20 - Debunking Common Genetic Myths
09:07 - Trauma, Mindset and Genetic Expression
16:20 - The Future of Personalized Medicine
23:06 - Dr. Sherwood's Daily Habits
29:57 - Key Takeaways and Resources
WEBVTT
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I always thought that disease process really began in the genes, but I realized the majority of our illnesses today are really this environmental cause and really not understanding how the genes can be controlled better.
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If you want to break the mold of traditional pharmacy and healthcare, you are in the right place.
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Welcome to the Pivoting Pharmacy with Nutrigenomics podcast.
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Here's a little truth bomb.
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We're all unique, down to our DNA, so it's no wonder we react differently to the same medications, foods and environment.
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Here's a million dollar question how can you discover exactly what your body needs, which medication, what foods or supplements and which exercises are right for you?
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How can you manage chronic conditions like diabetes without more medications?
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How can you lose weight and keep it off?
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How do you tap into your genetic blueprints so you can stop surviving and start thriving in health and life?
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That is the question, and this podcast will give you the answer.
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I'm your host, dr Tamar, lawful doctor of pharmacy.
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Let's pivot into genomics and bring healthcare to higher levels.
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Welcome back to Pivoting Pharmacy with Nutrigenomics, where we dig deep into the science, the mindset and sometimes even the messiness of our health journeys.
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I'm Dr Tamar, lawful doctor of pharmacy and certified nutritional genomic specialist, and I want to kick things off today with a little confession.
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I'll never forget the first time a client told me I don't even want to see my genetic test results.
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I'm afraid I'll find out something I can't change and you know what I get it.
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Many of us grow up believing our genes are a fixed destiny, something written in stone, handed down through our family tree, and there's nothing we can do about it.
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But what if I told you that your DNA is more like a story draft a rough script, and you get to revise it every single day through your choices, habits and environment?
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That's exactly what today's guest, Dr.
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Mark Sherwood, is here to unpack.
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Dr Sherwood has trained thousands of physicians around the world on the power of genetics, yet his own roots run through law enforcement, athletics and public speaking.
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His story is anything but ordinary, and neither is his message.
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Your genes don't dictate your health you do so.
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If you've ever worried about what's in your genes, today's conversation will give you the knowledge, the tools and, honestly, the hope you need to see your genes as a roadmap, not a prison sentence.
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From misunderstood SNPs to peptide-based medicine, to powerful mindset shifts, Dr.
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Sherwood takes us on a journey to see health in a whole new way.
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Listen in.
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Well, Dr.
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Sherwood.
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Welcome to Pivoting Pharmacy with Nutrigenomics.
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It's a pleasure to have you here with us today.
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Oh, my goodness, the pleasure is all mine.
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I've been looking forward to this.
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Thank you so much for having me.
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You are welcome Now.
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You've coached thousands worldwide and trained physicians in the genetic space, yet your roots also include law enforcement, athletics and public speaking.
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What drew you to explore genetics as a tool for healing and longevity?
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What a great question to start with.
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So law enforcement it seems like it has nothing to do with genetics, but it really does, Because I heard a phrase a long time ago when I was in law enforcement that law enforcement is rooted in your genes, and that got me curious.
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I thought is that true or not?
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So I started looking into it.
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Probably 2008 to 10 when we started to discuss this idea of genetics and it was after the Human Genome Project, of course, which that really didn't elicit what they wanted to get elicit with that, but I thought there was something to it.
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So I started studying on it and was fascinated by the individual single nucleotide polymorphisms and the effects that environment had on those and I just kind of like Forrest Gump, you know, started running.
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Well, I just kept on studying and never stopped.
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So there you go.
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Well run, forrest run.
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No doubt right.
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So when you first started working with genetic data, what was something that surprised or even challenged your assumptions about health and outcomes?
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Well, I always thought erroneously that disease process really began in the genes and that's just kind of a naive approach, you know, and it's fascinating that we're still thinking like that in some phases of the game today.
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But as I got into it I realized the environmental push or the expression of genes that's caused by the environment.
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That blew my mind because I had no idea about how much our own environments affect that and each individual person's environment.
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So you could have the same kind of snip in some areas but you have a different lifestyle and it can cause a different expression.
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So that really surprised me.
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I didn't really know that.
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And then I quickly determined that the majority of our illnesses today are really this environmental cause and really not understanding how the genes can be controlled better.
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Yeah, that's a good point, and we have a lot of buzzword around biohacking longevity- and using supplements, peptides, even sleep tracking, but how do genetics actually inform what works and what's just hype?
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When I look at like the genetics just for me, I'm looking at them as a roadmap that has been scripted for me.
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So these are the ones that have been carried over time, with the change in genetics only being 2% in 10,000 years or so.
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I look at it as the roadmap of what's supposed to happen.
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So for me it's a book of proteins and I want to know how to create and make those proteins function for me, as opposed to allowing them to function against me, not blaming the genes, but looking at the environment.
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So when I look at the genes, I'm looking at various combinations on what I can do.
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Just for a simple example, when you have the infamous MTHFR 677 or 1298 positions where they got SNPs, you know, a lot of people kind of freak out.
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I don't.
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I look at them and I think, okay, well, I've got to make sure I have my methylated B vitamins, I've got to make sure I have some magnesium and I'm even going to consider adding a little creatine to sort of salvage some methyl groups.
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So I'm looking at things ahead like that kind of in a proactive way as opposed to a negative way.
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Yeah, that's a good approach.
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Just work with them, yeah, I don't look at them as bad.
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I mean, I look at them as sort of information for me and I kind of like coach the people we deal with around the world to not look at them as a negative, because that's a big fear people have.
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I don't want to know my genes because I don't want to know.
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I'm like, yeah, you do want to know, because it's not disempowering but rather it's very empowering.
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Oh, yes indeed.
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Now, with the methylation genes you mentioned, a lot of people do hyper-focus on them and they can be overhyped.
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Are there any other SNPs that you see that are misunderstood versus what people should really?
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And maybe people are just over-fixating on these SNPs when there are some other things that they should probably pay more attention to.
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Yeah, just to kind of tie up the methylationary in a nice bow.
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If you're not looking at you know the MTRR, mtr, cbs, you know COMT, those other ones around there you're really misinformed.
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So there's too much hyper-focus on MTHFR because it's just, I look at it like one little dot on a big old wall and that's all it is.
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We may know a lot about it, but we don't know a lot about everything.
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And the more I study about genetics, the more I realize I don't know and it's fascinating.
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The other one that I see often overhyped or maybe misinterpreted is APOE4.
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You know, I look at that when people say, well, I'm going to get heart disease or I'm going to have Alzheimer's.
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No, you're not, because you can sit there and legitimately say that that APOE4 may be in 25% of the population.
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Okay, does that mean that 25% of the population is going to get Alzheimer's or heart disease?
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The answer is no, because so many multifactors.
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And so if you look at that one, interestingly enough historically it's more of a protector to the LDL molecule.
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So it's actually, if you can get your mind around this, it's actually kind of beneficial.
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If you can put that in a good environment, we can maintain more LDL in the blood for its proper dropping off of the cholesterol availability as needed, which is actually a good thing.
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But in today's world we've looked at cholesterol as a negative thing, so therefore it's a bad thing.
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So it's all about context, but that's one that I see often confused and with the idea of brain disease, as it's tied to that and there is an association there.
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But you know, like Alzheimer's, dementia is like type 3 diabetes and you look at the APOE4, well, that just interferes with the insulin degrading enzyme in the brain.
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So you're talking insulin resistance of the brain.
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So how do we stop that?
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Don't eat the standard American diet and then don't worry about it.
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Exactly, I love that you brought that point out.
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Just because you have that variation doesn't mean that that's your life sentence.
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You know there are things that you can do in your lifestyle and your environment to work with that, to prevent that from happening.
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So thanks for highlighting that those are very two common and important genes that people do bring up.
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Oh yeah, I see it all the time and probably some other ones.
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I see in the detox pathways some of the GSTs you know.
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They bring those up and they say, well, I'm missing one of my glutathione transferase enzymes, I'm like well, and do you think that's the only way or avenue your body has to facilitate proper detoxification?
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Absolutely not.
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When you look at some of the ones that are deleted anyway, like the deletions one and that's very common, you know 40, 50% of the population may have a deletion there.
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So I try not to like over-focus on those, but kind of focus around those so that people don't get polarizing on those things.
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Right, yeah, you can't just look at one.
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No, at all, and you can't just look at one.
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No.
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At all, and knowing your genes is just the starting point.
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The bigger question is what do you do with that information?
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So let's shift gears and talk about how we actually turn those insights into action, Because for most people, it's not the test results that are the problem.
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It's knowing how to apply them in a way that truly improves their day-to-day life.
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So you've seen thousands of DNA test results In your experience.
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What keeps people from applying what they learn?
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I think it's misinformation.
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I think it's misinformation about two areas specifically One that genes are bad and tangential with.
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That is the idea that genes create disease, and we know that that's not true, referring to the Human Genome Project, and they discovered that only 2% to 4% at most disease processes that we know are specifically tied to certain mutations.
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Right, but the rest of the 96% 98% is multifactorial.
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So I think it's the misinformation that's been broadcast out there and even some clinicians you know that make statements like you got upset about genes or you just got bad parents or whatever, and that's not really true.
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And I think the second thing is there's a lot of and I don't like that, it's done, but it is done that people will treat the SNPs instead of the person.
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In other words, here comes a SNP and so they don't assess the person.
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If they've got a polymorphism on the MTHFR, you know, 677 or something, they're just going to automatically assume they need X number of B vitamins.
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But that might not be true, because I want to actually test.
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I want to look at markers like homocysteine.
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I want to see what the body's doing in its current state.
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I might look at micronutrients to determine what's at the cell level.
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So all these things are very important, and the best way to understand the genes is know them, as you said.
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And then what can you do environmentally, from the things you can control, to help them express themselves in a known manner?
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And some of the environmental things that we can do is like exercise, sleep, stress management, vitamins and minerals, of course, and even some peptides.
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Yeah, yes, indeed.
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Now, along the lines of misinformation, I'm interested to know what's your take on direct-to-consumer testing.
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Is it a helpful first step or a potential misinformation trap?
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Yeah, I think it's potential misinformation trap and I base what I said just on history and I'm not.
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I wish it wasn't like this.
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But I go back and look at the BRCA1 and BRCA2 fiasco.
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You know that was the classic where people would get those tests from ABC company, let's just say, and then they would go out and it would put them in a fear mode and they would go out and request, you know, a double mastectomy, for example, hysterectomy Again completely unnecessary although I'm not a lady so I can't really say that I would understand.
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But that was treating something and that was provoking fear.
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And I think that whole concept of fear like that direct-to-consumer, could have been avoided with better education.
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And now fast forward to when it started getting more popular and it was just the DTC, the direct-to-consumer model out there big time.
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You had a lot of people developing their own theories about MTHFR, for example, and they would absolutely flip out.
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I've had many people walk into my office or I see them on Zoom and they would say this to me I have MTHFR, did you know that?
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And I stop and pause, honest to goodness.
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And it's pretty funny.
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My wife laughs at me all the time because I say that is like fascinating.
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I have that too, and they look at me like I'm from another planet.
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Right.
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I say what's fascinating is everybody has that and then that they're just.
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Their mind is blown at that point.
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So I think the direct consumer could be done better, but I think in today's world it leaves a lot to be desired.
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That's true, and education is definitely a major component of that and necessity.
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If we were going to do DTC, you know I want to shift the gears a little bit to go beyond the genes, because it's not just about what's in our DNA, it's what you do with it.
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So let's talk about the role of mindset, environment and the choice in genetic expression.
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Now, you and your wife, dr Michelle, you emphasize a whole person approach, right?
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Yes, how do things like trauma, mindset and community play into genetic expression and disease reversal?
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Well, they're at the top, Because when you look at a human being, okay, we're a body and inside of that we have all these cells with all these nuclei, with DNA, and we have this world we live in.
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That's highly traumatizing and anxiety riddled and it's a crazy thing, this thing called life.
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I've looked at life, I've said this it's like a 3D acid trip, not knowing where it's going to go, you know, but ultimately we have to factor in the whole person.
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When you look at a person that has internal trauma, you think about where that trauma came from and we know from the methylation capacity.
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Some of the methylation processes happen in utero.
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So you're talking about trauma that can go down generational lines and I've seen this hundreds of times.
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We know that a person lives in chronic trauma, chronic fear, chronic stress or hyper cortisolism, as I refer to it.
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They are not having good genetic expression anyway, because the body is smart.
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If we're driving cortisol tomorrow and we're driving that cortisol out there, the body recognizes that we're being chased by a bear out here that's going to eat us, that's trying to chase us and eat us down.
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So all the processes inside of our intracellular communication network, it's almost like a turtle going inside the shell.
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We have to hold everything and it goes on and on with that, and you know how that affects gut health as well.
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That's the same principles that I'm talking about.
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So it's fascinating about how that trauma that is today can drive that.
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And then you throw in social media, the connectivity that's always hitting that dopamine button with us.
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There's all this going on and we have to address that.
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It's a have to, because if we don't, it's not the genes causing the problem, it's that hyper-cortisolemic environment that's not allowing our genes that are favorable even to work for us.
00:16:21.659 --> 00:16:23.722
Yeah, well explained, beautifully explained.
00:16:23.722 --> 00:16:26.989
It's like our genes are going into protective mode.
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They are the whole cells.
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It's like they're not going to do anything.
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It's like I have to restrict anything right now, because if I stick my head out here it's going to get ate by the bear too, you know, and I'm being very demonstrative with that story.
00:16:39.970 --> 00:16:41.600
But that paints a good picture for people.
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Yeah, now, have you ever worked with someone who should have been healthy based on their genes but wasn't, or vice versa?
00:16:50.629 --> 00:16:55.913
Oh gosh, yes, you know, a lot of times we look at the genes as a dictator of health, and they're not.
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The genes really don't determine health, you do, you know, I think, if I this illustration really painted a picture for me years and years ago, here's your genes, right here.
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But over and above those is the environment.
00:17:09.433 --> 00:17:15.347
So this epigenetic interaction is superseded by the environment.
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So the environment's really the controller, the environment is the trigger of everything.
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Your body's just responding to that.
00:17:21.928 --> 00:17:25.441
And what do you do with the environment is up to you.
00:17:26.402 --> 00:17:34.666
And environment is perception of stress, you know, making stress a verb perhaps instead of a noun, which I always like to talk about.
00:17:34.666 --> 00:17:39.461
And then it's like looking at a situation and making a good decision with food.
00:17:39.461 --> 00:17:42.409
It's like deciding to go to bed earlier.
00:17:42.409 --> 00:17:44.472
It's deciding to get deeper sleep.
00:17:44.472 --> 00:17:47.287
It's deciding to go out and exercise or get for a walk.
00:17:47.287 --> 00:17:51.066
It's deciding to go out and get some sunshine as opposed to staying inside all day.
00:17:51.066 --> 00:17:55.805
It's deciding to breathe and relax as opposed to being all excited.
00:17:55.805 --> 00:18:00.621
We control the environment and we set the tone for the environment even by what we say.
00:18:00.621 --> 00:18:11.303
You know how many people today I'm scared of, I'm afraid of, or they own a condition that cannot be good for the environment internally or externally.
00:18:11.303 --> 00:18:18.391
So that sets the tone for how our genes are going to respond to that and they're going to create proteins to deal with whatever environment we create.
00:18:19.000 --> 00:18:19.780
That's a good point.
00:18:19.780 --> 00:18:29.930
You've painted this powerful picture, dr Sherwood, of how environment, mindset and personal choices influence, even override, our genetic blueprint.
00:18:29.930 --> 00:18:34.815
It's a reminder that we're not just passengers in our health journey, but we're active participants.
00:18:34.815 --> 00:18:37.537
We play a part in that journey.
00:18:37.537 --> 00:18:43.261
Mind, I want to look ahead.
00:18:43.261 --> 00:18:49.765
You've been on the front lines of nutrigenomics and functional medicine for years, so what trends, tools or breakthroughs do you see shaping the future of personalized care?
00:18:50.888 --> 00:19:17.824
I think some of the proteomics and metabolomics testing is going to be fascinating and I think really it's going to be found in the proteomics, as a matter of fact, because some of the metabolism measures from the proteomics processes are going to be fascinating because, like so, here's our genes that makes proteins I'm going to get people, for example and some of our proteins could be antibodies, like the immunoglobulin g, which is our most robust antibody.
00:19:17.824 --> 00:19:32.311
Well, one of the cool tests out there is a glycan test and it's a glycan age test and it looks at the sugar structures of those glycan structures around the IgG and based upon those structures we can understand how well our immune system is doing.
00:19:32.311 --> 00:19:35.080
Is it acting more youthful or is it acting old?
00:19:35.080 --> 00:19:37.628
Is it inflammatory, is it anti-inflammatory?
00:19:37.628 --> 00:19:42.623
And there's a correlating biological age driven from that test specifically.
00:19:42.623 --> 00:19:46.152
But the protein actually forms the glycans.
00:19:46.599 --> 00:19:51.506
So I think there's a whole world of science out here about what the proteins are going to do that we don't know.
00:19:51.506 --> 00:20:00.671
So the science of glycobiology perhaps is going to be something that's out there in the future and I think as well some of these metabolites that we're just starting to get our hands on.
00:20:00.671 --> 00:20:09.202
You look at some of these proteomic tests today that sort of correlate with disease processes or the aging process Fascinating, and I've been into that for years.
00:20:09.202 --> 00:20:12.131
But I think honestly those things are just on the tip edge.
00:20:12.131 --> 00:20:16.371
We don't know much about those and the more we get into those, the more we find out.
00:20:16.371 --> 00:20:18.161
So I think those things are some coming trends.
00:20:18.901 --> 00:20:26.385
Oh, that's really interesting and so much to forward to Now that we're getting the precision health and personalized health is.
00:20:26.385 --> 00:20:29.146
There's more research, more studies being done.
00:20:29.146 --> 00:20:32.630
There's so much more we have to look forward to, so it's an exciting future.
00:20:33.490 --> 00:20:38.782
No doubt, and I think one of the most coolest things out there and you're probably jumping the gun a little bit here is peptides.
00:20:38.782 --> 00:20:46.983
Not just the bigger peptides, but what about the bioregulator peptides, the ones that actually bind a specific DNA material inside the nucleus?
00:20:46.983 --> 00:20:50.119
That is incredibly intriguing to me.
00:20:50.119 --> 00:20:58.203
Can you make or override a system that might have susceptibilities or tendencies for weakness?
00:20:58.203 --> 00:21:02.421
And the potential is there, it really is, and what does that mean?
00:21:02.421 --> 00:21:05.877
I don't know, but it sure is exciting to wonder about it.
00:21:06.519 --> 00:21:06.941
Indeed.
00:21:06.941 --> 00:21:12.882
Wow, that's pretty amazing what we can do now with science to help our bodies and help our health.
00:21:12.882 --> 00:21:17.602
Now, dr Sherwood, you've trained practitioners worldwide when it comes to genomics.
00:21:17.602 --> 00:21:21.319
What are they asking you about now that they weren't asking five years ago?
00:21:22.030 --> 00:21:44.182
Well, I think it's getting better, but what happens is a lot of the times clinicians and you know I don't claim to be the smartest tack in the box, but I've learned over time how to understand my strengths and perhaps even growth through weaknesses but a lot of clinicians get hung up on one gene because they're taught to look for that one thing what is wrong with me?
00:21:44.371 --> 00:21:58.303
And they've got this mentality that says what is wrong, what is wrong, and they're always looking for what is wrong and they get stuck in those things and they just can't get past it that we live in this interdependent system, dominated body that looks at everything working together.
00:21:58.303 --> 00:22:05.936
I don't think we understand yet how everything works together so neatly and intricately, but I think we need to know it's understanding.
00:22:05.936 --> 00:22:12.782
So that's what I saw originally and I've seen a trend and a shift more towards systems biology, which is good.
00:22:12.782 --> 00:22:26.185
But I think we need to even go farther than that and start looking at, as you and I talked about, environment, what we say, the mental mindset, what we speak into our lives, what we do with our bodies, certainly what we eat.
00:22:26.185 --> 00:22:37.078
I think putting all that together is an opportunity and with this area, honestly, in the anti-aging, longevity, age management space, whatever you want to call it.
00:22:37.078 --> 00:22:41.483
We are just on the precipice of bigger and better things.
00:22:41.483 --> 00:22:42.786
Right now, we're just getting started.
00:22:43.450 --> 00:22:44.576
I agree 100%.
00:22:44.576 --> 00:22:48.040
I want to touch back on the peptide-based medicine.
00:22:48.040 --> 00:22:53.698
For those who are listening, this might be a new concept, new terminology they've heard before.
00:22:53.698 --> 00:23:00.894
Can you explain what the potential peptide-based medicine has when it comes to health?
00:23:01.355 --> 00:23:03.501
Well, I think it's important to understand what peptides are.
00:23:03.501 --> 00:23:07.826
They're nothing more than bonds of amino acids, and you know that.
00:23:07.826 --> 00:23:18.910
Well, they're structured together in a lab, but amino acids are natural for our body, so we're not looking at some kind of pharmaceutical thing that's a little bit foreign, or stops or starts a process abruptly that's supposed to start, or stops or starts a process abruptly.
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